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Prevalens dan karakteristik penderita retinoblastoma di RSUP Sanglah Denpasar pada tahun 2008-2015

Abstract

Retinoblastoma is the most common intraocular malignancy of childhood, with incidence 1 in 20.000 birth and 3-4% of all malignant tumors in children. There has been no data about the prevalence and characteristics of children with retinoblastoma in Sanglah Hospital, Denpasar. Aim of this study is to know prevalence and characteristics of children with retinoblastoma in Sanglah Hospital, Denpasar. This is retrospective study, conducted in Sanglah Hospital, Denpasar, performed  by data obtained from January 2008 to December 2015. The prevalence of retinoblastoma among children with solid tumor from January 2008 to December 2015 was 72% (59 of 82 cases). There were 75% cases unilateral and 25% bilateral. The female to male ratio was 1:1.2, with mean age when admitted was 31.4 (18.8 SD) months. There was 64% from Bali, 24% West Nusa Tenggara and 12% East Nusa Tenggara. Fourty six percent with well nourished and 37% mild malnourhised. The most common presenting sign when admitted was proptosis (64%) and leukocoria (27%). First leucocyte count 10.7 103/µL (3.5 SD), haemoglobin 11.7 g/dL (1.3 SD), platelet count 448 103/µL (188.5 SD) and 21 cases (36%) with thrombocytosis. The mortality was 68% and three cases (5%) lost to follow up. The Conclusions is prevalence of retinoblastoma in Sanglah Hospital was 72% with mortality 68%. Mostly occurs in males, mean age when admitted was 31.4 (18.8 SD) months, mostly unilateral, with the most common presenting sign was proptosis. Leucocytes and haemoglobin mostly normal and 36% with thrombocytosis.

 

 

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References

  1. Rosbiana N. Gambaran klinis dan laboratorium retinoblastoma. Sari Pediatri. 2011;5:319-22.
  2. Lanzkowsky P. Retinoblastoma. Dalam: Manual of pediatric hematology and oncology. Edisi ke-5. New York: Elsevier; 2011. h. 759-75.
  3. Hurwitz RL, Shields CL, Shields JA, Barrios PC, Hurwitz MY, Chintagumpala MM. Retinoblastoma. Dalam: Pizzo PA, Poplack DG, penyunting. Principles and practice of pediatric oncology. Edisi ke-4. Lipincott Williams & Wilkins; 2002. h. 825-46.
  4. Sutaryo, Hagung P. Retinoblastoma. Dalam: Permono B, Sutaryo, Ugrasena IDG, Windiastuti E, Abdulsalam M, penyunting. Buku ajar hemato-onkologi anak. Edisi ke-2. Jakarta: Badan penerbit IDAI; 2006. h. 302-9.
  5. Dharmawidiarini D, Prijanto, Soebagjo HD. Ocular survival rate penderita retinoblastoma yang telah dilakukan enukliasi atau eksenterasi di RSUD Dr. Soetomo Surabaya. JOI. 2010;7:94-102.
  6. Nabie R, Taheri N, Fard AM, Fouladi RF. Characteristic and clinical presentations of pediatric retinoblastoma in North-western Iran. Int J Ophtalmol. 2012;5:510-2.
  7. Watts P. Retinoblastoma: Clinical features and current concepts in management. J Indian Med Assoc. 2006;101:464-8.
  8. Dondey JC, Staffieri S, McKenzie J, Davie G, Elder J. Retinoblastoma in Victoria, 1976-2000: Changing management trends and outcomes. Clin Experiment Ophthalmol. 2006;32:354-9.
  9. Aerts E, Lumbroso L, Gauthiers-Villars M, Brisse H, Doz F, Desjardins L. Retinoblastoma. Orphanet Journal of Rare Diseases. 2006;1:31.
  10. Xin LUO, Huijing LE, Yun-Gang D, Yi D, Huasheng Y. Clinical characteristic and prognosis of patients with retinoblastoma: 8-year follow-up. Turk J Med Sci. 2015;45:1256-62.
  11. Abramson DH, Beaverson K, Sangani P. Screening for retinoblastoma: presenting signs as prognostic factors of patient and ocular survival. Official Journal of the American Academy of Pediatrics. 2006;112:1248.
  12. Dahlan MS. Besar sampel dan cara pengambilan sampel dalam penelitian kedokteran dan kesehatan. Edisi ke-2. Jakarta: Salemba Medika; 2009.h.38-9.
  13. Gavhane YN, Shete AS, Bhagat AK, Shinde VR, Bhong KK, Khairnar GA, dkk. Solid tumours: facts, challenges and solutions. International Journal of Pharma Sciences and Research. 2011;2:1-12.
  14. Sjarif DR. Prinsip asuhan nutrisi pada anak. Dalam: Sjarif DA, Lestari ED, Mexitalia M, Nasar SS, penyunting. Buku ajar nutrisi pediatrik dan penyakit metabolik. Edisi ke-1. Jakarta: Badan penerbit IDAI; 2011.h.36-9.
  15. Lubis B, RoSBiana N. Trombositosis. Dalam: Permono B, Sutaryo, Ugrasena IDG, Windiastuti E, Abdulsalam M, penyunting. Buku ajar hemato-onkologi anak. Edisi ke-2. Jakarta: Badan Penerbit IDAI; 2006.h.302-9.
  16. Nafianli S. Retinoblastoma in children in Haji Adam Malik Hospital Medan. Majalah Kedokteran Nusantara. 2006;39:147-50.
  17. Yi-Jin Gao, Qian J, Yue H, Yuan Y, Xue K, Yao Y. Clinical characteristic and treatment outcome of children with intraocular retinoblastoma: a report from a Chineese cooperative group. Pediatr Blood Cancer. 2011;57:1113-6.
  18. Ozkan A, Pazarli H, Celkan T, Karaman S, Apak H, Kaner G, dkk. Retinoblastoma in Turkey: survival and clinical characteristic 1981-2004. Pediatrics International. 2006;48:369-73.
  19. Broaddus E, Topham A, Singh AD. Incidence of retinoblastoma in the USA: 1975-2004. Br J Ophtalmol. 2009;93:21-3.
  20. Ramirez-Ortiz MA, Ponce-Castaneda MV, Cabrera-Munoz ML, Medina-Samson A, Liu X, Orjuela MA. Diagnostic delay and sociodemoghrapic predictors of stage at diagnosis and mortality in unilateral and bilateral retinoblastoma. Cancer Epidemiol Biomarkers Prev. 2014;23.
  21. Garofolo A, Lopez FA, Petrilli AS. High prevalence of malnutrition among patients with solid non-hematological tumors as found by using skinfold and circumference measurements. Sao Paulo Med J. 2006;123:277-81.

How to Cite

Yani Lastariana, K. A., Ariawati, K., & Widnyana, P. (2018). Prevalens dan karakteristik penderita retinoblastoma di RSUP Sanglah Denpasar pada tahun 2008-2015. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.109

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