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Sindrom metabolik merupakan faktor risiko terjadinya psoriasis



Abstract

Pendahuluan: Psoriasis merupakan penyakit kulit in amasi kronis yang dicirikan oleh lesi berupa papul dan plak eritema dengan skuama tebal, kasar, kering serta berwarna putih keperakan. Penyakit dengan prevalensi bervariasi dari 1% sampai 3% di dunia ini umumnya dijumpai pada area predisposisi seperti kulit kepala, ekstensor, bokong, tangan, kaki, serta genitalia. Penderita psoriasis sering kali mengalami penyakit komorbid lain seperti sindrom metabolik, penyakit kardiovaskular, artritis rematoid, penyakit Crohn, kolitis ulserativa, limfoma Hodgkin, limfoma sel-T kutis dan berbagai kelainan psikologis. Sindrom metabolik dide nisikan sebagai kumpulan faktor risiko kardiometabolik yaitu obesitas sentral, hiperlipidemia, hipertensi, dan resistensi insulin. Penelitian ini bertujuan untuk membuktikan bahwa sindrom metabolik merupakan faktor risiko terjadinya psoriasis.

Bahan dan Metode: Penelitian case-control ini dilakukan di Poliklinik Kulit dan Kelamin RSUP Sanglah Denpasar selama periode 1 November 2016 hingga 1 Januari 2017. Populasi terjangkau adalah semua pasien psoriasis yang berkunjung ke Poliklinik Kulit dan Kelamin RSUP Sanglah Denpasar selama rentang waktu tersebut.

Hasil: Hasil penelitian ini memperoleh bahwa sindrom metabolik meningkatkan risiko terjadinya psoriasis [RO=12,3 (IK95%=3,4 sampai 44,2), P < 0,001], sehingga disimpulkan bahwa sindrom metabolik merupakan faktor risiko psoriasis.

Kesimpulan: Sindrom metabolik merupakan faktor risiko terjadinya psoriasis.

 

Introduction: Psoriasis is a chronic in ammatory skin disease characterized by erythematous papules and plaques covered by white to silvery dry, coarse and thick scales. The disease with prevalence 1-3% around the world is usually found on predisposing areas such as scalp, extensor extremities, hands, feet, and genitalia. Patients with psoriasis often have other comorbid diseases such as metabolic syndrome, cardiovascular disease, rheumatoid arthritis, Crohn disease, ulcerative colitis, Hodgkin lymphoma, cutaneous T-cell lymphoma, and psychological disorders. Metabolic syndrome was de ned as the presence of cardiometabolic risk factors such as central obesity, hyperlipidemia, hypertension, and insulin. This case-control study was conducted to prove if metabolic syndrome is a risk factor of psoriasis. resistance.

Method: This case-control study is conducted in Dermatology Polyclinic of Sanglah General Hospital from 1st November 2016 to 1st January 2017. The target population is all patients visiting the polyclinic during the time period.

Result: The result of this study shows that metabolic syndrome increases the risk of psoriasis [OR=12.3 (95%CI=3.4 to 44.2), P <0.001]. It was concluded that metabolic syndrome is a risk factor of psoriasis.

Conclusion: Metablic syndrome is a risk factor of psoriasis

Keywords: psoriasis metabolic syndrome International Diabetes Federation

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How to Cite

Kris, M. V., Adiguna, M. S., & Wardhana, M. (2019). Sindrom metabolik merupakan faktor risiko terjadinya psoriasis. Medicina, 50(2). https://doi.org/10.15562/medicina.v50i2.118
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Made Veranita Kris
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Made Swastika Adiguna
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Made Wardhana
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