Skip to main content Skip to main navigation menu Skip to site footer

Ekspresi kolagen III pada ligamentum sakrouterina wanita paskamenopoause lebih rendah dari wanita premenopause



Abstract

Recently, etiology causing pelvic organ prolapse are remain unknown. There is some evidence that abnormalities of the connective tissue composition may contribute to the pathogenesis of pelvic organ prolapse. The most important connective tissue in pelvic support system is uterosacral ligament. Menopause is a significant risk factor for pelvic organ prolapse because of decreasing estrogen hormone can influence collagen metabolism. This study was a cross-sectional design aim to understand whether collagen III expression at uterosacral ligament in postmenopausal women is lower than premenopausal women. This study was conducted since October 24th 2015 until October 23rd 2016. Among 60 women who underwent total hyterectomy at Sanglah General Hospital, Denpasar studied, 30 women already postmenopause and 30 women still premenopause. Collagen III expression at uterosacral ligament was analyzed in Animal Medicine Faculty and Histology Department of Medical Faculty Udayana University, Denpasar. Data was statistically analyzed with Shapiro-Wilk test and Levene test for normality and homogenity, then analyzed with independent sample test. The result of this study was the mean collagen III expresion at uterosacral ligament postmenopausal women is 39.87+17.48%. Meanwhile the mean colagen III expresion at uterosacral ligament premenopausal women is 69.12+12.64%. Analysis of significance with independent t-test concluded that the value of t = 7.43 and P = 0.001, showing that collagen III expresion at uterosacral ligament postmenopausal women is differ with premenopausal women significantly (p<0.05). This research conclude that collagen III expresion at uterosacral ligament of postmenopausal women was lower than premenopausal women.

 

 

Keywords: collagen III uterosacral ligament postmenopausal premenopausal

References

  1. Jelovsek JE, Maher C, Barber MD. Pelvic organ prolapse. Lancet. 2007; 369:1027-38
  2. Kerkhof MH, Hendriks L, Brolmann H. Changes in connective tissue in patient with pelvic organ prolapse – a review of the current literature. Int Urogynecol J. 2009;20:461-474
  3. Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A. Pelvic organ prolapse in the women’s health initiative: gravity and gravidity. Am J Obst Gynecol. 2002;186:1160-1166
  4. Ewies AA, Al Azzawi F, Thompson, J. Changes in extracellular matrix protein in cardinal ligaments of post menopausal women with or without prolapse : a computerize immunohistomorphometric analysis. European Society of Human Reproduction and Embryology. 2003;18:2189-2195
  5. Moalli PA, Talarico LC, Sung VW, Klingensmith BS, Shand, BS, Meyn MS, dkk. Impact of menopause on collagen subtype in the arcus tendineus fasciae pelvis. Am J Obstet Gynecol. 2004;190:620-627
  6. Han LY, Wang L, Wang Q, Li HL, Zang H. Association between pelvic organ prolapse and stress urinary incontinence with collagen. Exp Ther Med. 2014; 7(5):1337-1341
  7. Gabriel B, Denschlag D, Gobel H, Fittkow C, Werner M, Gitsch G, dkk. Uterosacral ligament in postmenopause women with or without pelvic organ prolapse. Int Urogynecol J. 2010;16:475-479
  8. Irawan AR, Ermawati, Bachtiar H. Perbedaan ekspresi kolagen tipe III ligamentum sakrouterina antara pasien prolap uteri dengan pasien tanpa prolap uteri [thesis]. Universitas Andalas; 2016
  9. Aznal SS, Meng FK, Nalliah S, Tay A, Chinniah K, Jamli MF. Biochemical evaluation of the supporting structure of pelvic organs in selected numbers of premenopausal and postmenopausal malaysian women. Indian J Pathol Microbiol. 2012;55:450-455
  10. Luo X, Shuo HL, Wang XY, Jiang XF, Xie JY. Change of collagen content in uterine ligament of perimenopausal women with relaxation of pelvic support. Zhonghua Fu Chan Ke Za Zhi. 2008;43(6):422-424
  11. Moalli PA, Shand SH, Zyczynski HM, Gordy SC. Remodelling of vaginal connective tissue in patient with prolapse. ACOG. 2005;106(5): 953-963
  12. Ramanah R, Berger MB, Parrate BM, DeLancey JO. Anatomy and histology of apical support: a literature review concerning cardinal and uterosacral ligaments. Int Urogynecol. 2012;23:1483-1494
  13. Luo N, Guan Q, Zheng L, Qu X, Dai H, Cheng Z. Estrogen mediated activation of fibroblast and its effects on the fibroid cell proliferation. Transl Res. 2014; 163(3):232-241
  14. Reay Jones NH, Healy JC, King LJ, Saini S, Shousha S, Mersh TG. Pelvic connective tissue resilience decreases with vaginal delivery, menopause and uterine prolapse. Br J Surg. 2003;90:466-472
  15. Clark AL, Slayden OD, Hettrich K, Brenner RM. Estrogen increase collagen I and III mRNA expression in the pelvic suppoert tissue of the rhesus macaque. Am J Obstet Gynecol. 2005;192:80-88
  16. Philips CH, Anthony F, Benyon C. Collagen metabolism in the uterosacral ligaments and vaginal skin of women with uterine prolapsed. BJOG. 2005; 113:39-46
  17. Moalli PA. Debes KM, Meyn LA, Howden N, Abramowitch SD. Hormones restore biomechanical properties of the vagina and supportive tissue after surgical menopause in young tats. Am J Obstet Gynecol. 2008;199(2):161.e1-161.e8
  18. Rahn DD, Carberry C, Murphy M. Vaginal estrogen for genitourinary syndrome of menopause. Obstet Gynecol. 2014;124(6):1147-1156
  19. Chen B, Wen Y, Wang HP, Polan ML. Difference in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent woman. Am J Obstet Gynecol. 2003;189:59-65

How to Cite

Hadipranata, S., Suwiyoga, K., & Megadhana, W. (2018). Ekspresi kolagen III pada ligamentum sakrouterina wanita paskamenopoause lebih rendah dari wanita premenopause. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.133
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
21

Total
17

Share

Search Panel

Soedarsono Hadipranata
Google Scholar
Pubmed
Medicina Journal

Ketut Suwiyoga
Google Scholar
Pubmed
Medicina Journal

Wayan Megadhana
Google Scholar
Pubmed
Medicina Journal