Study of the Brain Natriuretic Peptide in blood plasma after pneumonectomy and its role as a predictor of postoperative complications
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- DOI: https://doi.org/10.15562/medicina.v49i2.137 |
- Published: 2018-08-12
Open Access & Peer Reviewed
Multidisciplinary Medical Journal
Multidisciplinary Medical Journal
Abstract
Objectives: The Brain Natriuretic peptide (BNP) is a peptide responsible for the homeostasis of the cardiovascular system.Â
In this study, the kinetics of BNP blood plasma levels after pneumonectomy, where certain hemodynamic alterations do occur, are analyzed and a possible predictive value of postoperative complications is examined.Â
Methods: Thirty-five patients enrolled, underwent a scheduled pneumonectomy for non-small cell cancer of the lung. The BNP plasma levels were recorded pre-operatively, immediately after the ligation of pulmonary artery, at 3 and at 24 hours postoperatively.Â
The collected data were analyzed with descriptive statistical analysis, using students t-test Chi-square, ANOVA, and Pearson’s correlation coefficient. The differences considered significant at p < 0.05.Â
Results: BNP showed a statistically significant increase after the ligation of the pulmonary artery in all of the patients. The patients were divided into 2 groups according to the presence or not of the complications. In the complications group the BNP increase was significantly greater than in the non-complication group. There is direct correlation of BNP value at 24 hours post-operatively and the occurrence of complications. The cut-off value was set at 100pgr/ml (sensitivity 91,6% and specificity 93.75%). Pre operatively BNP values above 15pgr/ml have 17,41% probability for a complication to occur. (60% sensitivity and 70.83% specificity)
Conclusion: The results of the study of the BNP after pneumonectomy are interesting and are in the path of a safety and economical routine clinical use for the prediction and prevention of post-operative complications.Â
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How to Cite
Baltayiannis, N., Tsimpinos, M., Grisbolaki, E., Chatzimichalis, A., & Tomos, P. (2018). Study of the Brain Natriuretic Peptide in blood plasma after pneumonectomy and its role as a predictor of postoperative complications. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.137
