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Ekspresi kolagen I, elastin, dan ketebalan epitel dinding vagina paskamenopause lebih rendah dibandingkan premenopause


Menopause is defined as a situation in which the cessation of menstruation in women occur permanently because of the state of hypoestrogenic due to decreased function of the ovaries. This can lead to changes in many systems and organs of the body. Changes to the vulva and vagina can also occur, including atrophy of the vaginal, cervical atrophy and weakness in the pelvic floor. The vagina consists of non-keratinizing squamous epithelium, lamina propria, the muscle layer, and adventitia layer consisting of collagen and elastin. Only little is known about the characteristics of histo-morphology of the vaginal walls and changes in the connective tissue in menopausal women. Because of this, the study aims to determine differences in the expression of collagen I, elastin and ephitelial thickness of the vaginal wall between premenopausal and postmenopausal. The research design use analytic observational cross-sectional study. Research conducted in Sanglah Hospital Denpasar starting in January 2016 until December 2016. Samples were taken from the vaginal wall of premenopausal and postmenopausal women who have made a total hysterectomy on indications of  prolapse uterine or benign abnormalities of the uterine. A total of 24 patients who did a total hysterectomy divided into 10 premenopausal patients and 14 postmenopausal patients. Data was processed using SPSS 17.0 for windows® version. Based on Fisher’s Exact analysis test on a 2x2 cross table, the expression of collagen I RP=10.00; 95% CI=1.56-64.20; p=0.001. Elastin expression RP=9.29; 95% CI=1.44-59.95; p=0.001. And ephitelial thicknes of the vaginal wall RP=2.50; 95% CI=1.70-5.34; p=0.001. The results of this study concluded that the expression of collagen I, elastin and ephitelial thickness of the vaginal wall in postmenopausal lower than premenopausal.




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How to Cite

Eka Adnyana, I. G. H., Suwiyoga, K., & Megadhana, W. (2018). Ekspresi kolagen I, elastin, dan ketebalan epitel dinding vagina paskamenopause lebih rendah dibandingkan premenopause. Medicina, 49(2).




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