Pemberian rivaroxaban menurunkan kadar D-dimer pada operasi fiksasi interna tulang panjang ekstremitas bawah
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- DOI: https://doi.org/10.15562/medicina.v49i2.168  |
- Published: 2018-07-15
Deep Vein Thrombosis (DVT), oftenly become post operative complication on long bone internal fixation procedure and might leading to high morbidity to patients. D-Dimer is a fibrin degradation product which may become accurate marker for DVT. This research purpose is to prove that administration of Rivaroxaban in lowering D-Dimer level post operatively after internal fixation of lower extremities long bone.
Â Â Â Â Â Â Â Â Â Â Â Â Â This researchÂ is pre post experimental test with double blind sampling which consist of 40 samples, which is divided into 2 groups containsÂ 20 samples each. First group was given 10 mg Rivaroxaban per oral 6 - 10 hours post-operation, on the second groupÂ was given placebo. D-Dimer level checked in 1 day pre-operative, 1 day post-operative and 3 days post-operative.
Â Â Â Â Â Â Â Â Â Â Â Â Â Â D-DimerÂ mean measured in Rivaroxaban group, pre-operative 0.54 mg/L, 1 day post-operative 1.17 mg/L, 3 days post-operative 1.03 mg/L. D-DimerÂ Mean result in placebo group, pre-operative 0.77 mg/L, 1 day post-operative 5.74 mg/L, 3 days post-operativeÂ 3.89 mg/L. This research using independent t-Test in pre operative in both groups with no difference with significance of 0.07 (p>0.05), 1 day post operative with significance 0.002 (p<0.05) and on 3 days post-operative with significance 0.002 (p<0.05).
Â Â Â Â Â Â Â Â Â Â Â Â Â This research proves that administration of Rivaroxaban decreasing D-Dimer level on lower extremities long bone internal fixation operation. This result support that Rivaroxabanas is an effective thromboprophylaxis medicamentosa to DVT.