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Interleukin-6 receptor antagonist use in systemic juvenile idiopathic arthritis: a case report



Abstract

Systemic onset Juvenile Idiopathic Arthritis (JIA) accounts for approximately 4-15% of JIA, and has the worst prognosis. Treatment option in SJIA is still limited. Interleukin-6 receptor antagonist is the second line therapy, has been used widely in adult rheumatoid arthritis patients, but no report of pediatric population in Indonesia. To report the efficacy of interleukin-6 receptor antagonist-Tocilizumab in difficult to treat-SJIA management. An 11-years old boy was diagnosed with SJIA and treated with Ibuprofen, then switched to high dose pulse steroid therapy, continued by weekly methotrexate for 6 weeks, however flare up color the clinical manifestation. Following ACR Guideline 2013, tocilizumab every 2 weeks was started. After 4 weeks, the MD Global scores reduced from 10.7 to 3, ACR 70 was achieved, no systemic manifestations were found with normal lab result. Tocilizumab shows beneficial effects in SJIA patient

 

Keywords: interleukin-6 antagonist systemic juvenile idiopathic arthritis

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How to Cite

Mayasari, N. M. C., Kumara Wati, K. D., & Santosa, H. (2018). Interleukin-6 receptor antagonist use in systemic juvenile idiopathic arthritis: a case report. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.175
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Ni Made Chandra Mayasari
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Ketut Dewi Kumara Wati
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Hendra Santosa
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