Terdapat hubungan kadar estradiol dengan ekspresi kolagen dan elastin pada vagina premenopause dan pascamenopause

I Gusti Ayu Purjuniatni; Ketut Suwiyoga; I Wayan Megadhana

doi:10.15562/medicina.v49i2.244

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Terdapat hubungan kadar estradiol dengan ekspresi kolagen dan elastin pada vagina premenopause dan pascamenopause

I Gusti Ayu Purjuniatni ,

Ketut Suwiyoga ,

I Wayan Megadhana ,

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DOI: https://doi.org/10.15562/medicina.v49i2.244 |
Published: 2018-09-12

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Abstract

Menopause is women finalÂ menstrual period, the period of time before that point is known asÂ premenopause, and 12 months after that point is known as postmenopause. In postmenopausal women, estrogen Â level will decrease andÂ there will be vaginal integrity disorder due to decreasing collagen and elastin level which are the part of extracellular matrix. Previous studies have discussed about the correlation of collagen and elastin expression with the prevalence of pelvic organ prolaps but only few that discussed its correlation to menopause state in which the level of estrogen is decreasing. Objective, to determine correlation ofÂ estradiol level with collagen and elastin expression in premenopausal and postmenopausal vagina.This is a cross-sectional study. Samples are patients who did a total hysterectomy with indication pelvic organ prolapse and benign gynecologicÂ abnormalities. Twenty four samples included 10 premenopause patients and 14 postmenopause patients. Patient was examined for estradiol serum Â levels and expression of vaginal collagen and elastin. Pearson correlation test was used Â to determine the relationship between estradiol levels with expression of collagen and elastin vagina. PatientÂ mean age was 51.21 Â± 9.31 years with range of 35 to 67 years, mean of parity wasÂ 2.75 Â± 1.15 withÂ range Â 0 to 5, and mean of body mass index was 23.52 Â± 2 , 78 with range Â 21.09 and 32.4. Correlation ofÂ estradiol level with collagen expression in premenopausal and postmenopausal vagina r=0,67; p=0,001. Correlation ofÂ estradiol level with elastin expression r=0,73; p=0,001. Â Â The results of this study concluded that estradiol Â level correlate with collagen and elastin expression Â in premenopausal and postmenopausal vagina.

Keywords: estradiol collagen expression elastin expression premenopausal and postmenopausal vagina.

How to Cite

Ayu Purjuniatni, I. G., Suwiyoga, K., & Megadhana, I. W. (2018). Terdapat hubungan kadar estradiol dengan ekspresi kolagen dan elastin pada vagina premenopause dan pascamenopause. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.244