Pleomorphic giant cell anaplastic carcinoma  arising in struma ovarii

I Gusti Ayu Ari Kusumawati; Ni Wayan Winarti

doi:10.15562/medicina.v49i2.269

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Pleomorphic giant cell anaplastic carcinoma arising in struma ovarii

I Gusti Ayu Ari Kusumawati ,

Ni Wayan Winarti ,

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DOI: https://doi.org/10.15562/medicina.v49i2.269 |
Published: 2018-07-19

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Abstract

Monodermal teratoma consist of predominantly (>50%) or all component are thyroid tissue called struma ovarii. Malignant transformation of struma ovarii is very rare. Anaplastic carcinoma is the most rare type. A 52 years female with chief complaint of malaise and mass on lower abdomen. CT scan showed solid mass in ovarium that extend to upper abdominal cavity. CA-125 level is elevated. The frozen section was conducted, macroscopically showedÂ tumor size is 15 cm, mostly composed of necrotic area, others are multicystic and solid area. Microscopic examination showed most are necrotic tissue with anaplastic cells in solid form, infiltrative between stromal with scattered pleomorphic giant cells. Benign struma ovarii component are found. The diagnosis was confirmed by examination of paraffin blocks from remain frozen section tissue, showed the same result. One area showed well differentiated carcinoma of papillary carcinoma follicular variant. Tumor was diagnosed as pleomorphic giant cell anaplastic carcinoma arising in struma ovarii based on clinical data, laboratory, radiological, macroscopic, and histopathology findings.

Keywords: Struma ovarii malignant transformation thyroid-type carcinoma anaplastic carcinoma.

How to Cite

Kusumawati, I. G. A. A., & Winarti, N. W. (2018). Pleomorphic giant cell anaplastic carcinoma arising in struma ovarii. Medicina, 49(2). https://doi.org/10.15562/medicina.v49i2.269