Skip to main content Skip to main navigation menu Skip to site footer

Korelasi albumin serum dan interleukin-6 (IL-6) serum pada pasien geriatri di RSUP Sanglah Denpasar Bali Indonesia



Abstract

Pendahuluan: Albumin adalah suatu protein yang penting dalam proses penyembuhan luka dan apabila kehilangan protein akan menghambat proses penyembuhan luka. Kebutuhan protein meningkat saat terjadi cedera, untuk proses in amasi, imunitas dan pembentukan jaringan granulasi. Saat in amasi, terjadi peningkatan jumlah sitokin khususnya IL-6 yang bertanggung-jawab pada fase akut. Peningkatan sitokin ini menyebabkan terjadinya penarikan albumin dari intravaskuler ke dalam hati dan sirkulasi hingga proses in amasi selesai. Tujuan penelitian ini adalah mengetahui hubungan albumin serum dan IL-6 serum pada pasien geriatri.

Bahan dan Metode: Penelitian ini menggunakan studi observasional dengan rancangan potong lintang analitik, pengambilan sampel dengan cara konsekutif. Subjek adalah pasien geriatri (usia ≥60 tahun) yang dirawat di RSUP Sanglah, Denpasar, Bali, Indonesia antara November 2014-Pebruari 2015 (n=71). Kadar albumin serum diukur di laboratorium RSUP Sanglah menggunakan bromcresol green method dan kadar IL-6 serum menggunakan Human Interleukin 6 Immunoassay (Quantikine)kit. Uji statistik menggunakan uji non- parametrik Spearman.

Hasil: Adapun hasil penelitian ini yaitu terdapat korelasi negatif signi kan antara albumin serum dan IL-6 serum (r=-0,305; P=0,009).
Kesimpulan: Semakin tinggi kadar IL-6 serum maka semakin rendah kadar albumin serum.

 

Introduction: Albumin is a protein in the blood that is necessary for wound healing and if the lack of protein can inhibit wound healing. Protein requirements increase during injury, for in ammatory processes, immunity and granulation tissue formation. During in ammation, an increase in the number of cytokines especially IL-6 is responsible for the acute phase. This resulted in increased cytokine, drawn albumin from the intravascular to the liver and circulates until the in ammatory process is completed. The objective of this study was to study the correlation of albumin serum andIL-6 serum among elderly patients.

Method: Cross-sectional design using the analytical observational was conducted with consecutive sampling. Subject is elderly patients (≥60 years) admitted to RSUP Sanglah Denpasar, Bali, Indonesia, between November 2014-February 2015 (n=72). Albumin serum level was examined in the laboratory using bromcresol green method andIL-6 serum assessed using Human Interleukin 6 Immunoassay (Quantikine) kit. Statistical test using nonparametric spearmen’s test.

Result: There was signi cant negative correlation between albumin serum and IL-6 serum (r=-0.305; P=0.009).


Conclusion: If the IL-6 serum is increasing, it will make the albumin serum decreasing.

 

Keywords: albumin IL-6 elderly patients

References

  1. Soemantri AG, Setiati ET. Manifestasi Klinis Kegawatan Anak. Jilid 2. Pelita Insani. Semarang.2009.
  2. Ballmer PE. Causes and mechanisms of hypoalbumin- emia. Clinical Nutrition. 2001;20(3):271-3.
  3. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. e pro and anti in ammatory properties of the cyto- kine interleukine-6 biochemicia et biophysica acta 2011;1813:878-888.
  4. Guthrie RD Jr, Hines C Jr. Use of intravenous albumin in the critically ill patient. Am J Gastroenterol. 1991;86:255-63.
  5. Nicholson JP, Wolmarans MR, Park GR. e role of albu- min in critical illness. Br J Anaesth 2000; 85:599-601.
  6. Peralta R et al. Hypoalbuminemia clinical presentation. Di
  7. akses dari www.emedicine.medscape.com. (tanggal akses :
  8. Juli 2016).
  9. Goldwasser P, Fielman J. Association of serum albumin
  10. and mortality risk. J ClinEpidemiol. 1997;50(6):693-703.
  11. Short MA. Linking the sepsis triad of in amation, coag- ulation and suppresed brinolysis to infants. Adv Neonat Care 2004;5:258-73.
  12. Brock F, Betinelli L, Dobner T, Stobbe J, Pommati G, Telles C. Prevalence of hypoalbuminemia and nutritional issues in hospitalized elders. Rev Lat Am Enfermagem. 2016;24:1-8.
  13. Utariani A, Prasetyo B, dan Nugraha J. Correlation between the use of albumin infusion and concentrations ofserum albumin, proin ammatory cytokines (tnf-α, IL-6) and sofa score inseptic patients. Folia Med Ind. 2016;52(4):310-315.
  14. Arie U, 2011. Disertasi: Pengaruh infus albumin padape- rubahan kadar albumin serum, sitokinproin amasi(T- NF-α, IL1, IL6), CRP, MMP8 dan ekspresiEGFR, ERK1, ERK2, TGF-β, kolagen, MMP8 jaringanterhadap percepa- tan penyembuhan luka.
  15. Brown P. Malnutrition leading cause of deathin post war Angola. Bull World Health Organ. 2003;81:849-50.

How to Cite

Sri Rejeki, N. M. D. P., & Kuswardhani, R. T. (2019). Korelasi albumin serum dan interleukin-6 (IL-6) serum pada pasien geriatri di RSUP Sanglah Denpasar Bali Indonesia. Medicina, 50(2). https://doi.org/10.15562/medicina.v50i2.301
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
160

Total
144

Share

Search Panel

Ni Made Darma Patni Sri Rejeki
Google Scholar
Pubmed
Medicina Journal

R.A. Tuty Kuswardhani
Google Scholar
Pubmed
Medicina Journal