Prolong Joint immobilization can lead cartilage damage. One of mechanism is release of proteolitic enzim such as MMP3. Simvastatin has capacity to become anti proteolitic enzyme which is released by chondrocyte. Oral simvastatin administration on joint immobilization can prevent cartilage damage monitored by lower serum COMP level and higher chondrocyte number on cartilage compared without simvastatin administration.This research was Randomized post-test only group design consists of 38 female rabbit as subject. All of rabbit’s knee were immobilized by cast and divided into 2 group. First group with no simvastatin administration and second group with oral simvastatin administration 20mg/kg/day for 6 week. Chondrocyte number on cartilage and serum COMP level was measured at the end of the six weeks study.Statistic analysis showed higher chondrocyte number and lower serum COMP level of rabbit’sknee with simvastatin administration compared with group rabbit with no simvastatin administration. Independent t-test analysis showed that difference were significant, with serum COMP p = 0.000 (p < 0.05) and chondrocyte number p = 0.000 (p< 0.05).Oral simvastatin administration on rabbit with knee joint immobilization have higher chondrocyte number and lower serum COMP level compared with group with no simvastatin administration.
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immobilization, simvastatin, chondrocyte, COMP
