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Faktor risiko yang mempengaruhi pembesaran volume prostat pada pasien pembesaran prostat jinak yang dilakukan reseksi prostat transuretra



Abstract

Pendahuluan:

Pembesaran prostat jinak atau benign prostatic hyperplasia (BPH) adalah penyakit degeneratif pria yang sering dijumpai. Banyak faktor yang diduga berperan dalam proliferasi jinak kelenjar prostat. Penelitian yang telah ada sebelumnya belum menyatakan faktor risiko mana yang paling berperan terhadap terjadinya BPH. Penulis mencoba mencari tahu faktor risiko mana di antara usia, infeksi saluran kemih, diabetes melitus (DM tipe 2), obesitas, dislipidemia, kadar testosteron, kadar PSA, serta kadar TNF-α dan kadar TGF-β jaringan prostat yang paling berperan dalam volume prostat.

Bahan dan Metode:
Penelitian ini menggunakan rancangan analitik kohort retrospektif dengan data diambil dari rekam medis, dengan melibatkan 83 subjek penelitian yaitu pasien BPH berusia 50-80 tahun yang dilakukan reseksi prostat transuretra di Bali dengan hasil pemeriksaan histopatologi jinak. Tidak didapatkan perbedaan yang bermakna pada karakteristik subjek penelitian. Analisis bivariat (uji Spearman) untuk mencari hubungan antara faktor risiko dengan volume prostat.

Hasil:

Terdapat korelasi positif antara kadar PSA dengan volume prostat (p<0,001) dan kadar testosteron dengan volume prostat (p=0,059, moderate signifikan). Analisis multivariat (regresi linier) didapatkan faktor risiko yang berpengaruh terhadap volume prostat adalah kadar PSA dan testosteron. Setiap peningkatan 1 ng/ml PSA serum akan meningkatkan volume prostat sebesar 1,4 ml (p<0,001) dan setiap peningkatan 1 ng/ml hormon testosteron akan meningkatkan volume prostat sebesar 0,024 ml (p=0,005). Kadar PSA dan kadar testosteron merupakan faktor risiko yang paling berpengaruh terhadap volume prostat.


Introduction:
Benign Prostatic Hyperplasia (BPH) is a common degenerative disease. Many contributing factors that affect benign prostatic proliferation. Many previous studies have not concluded which factors most affecting BPH. This study is aimed at figuring out whether aging, urinary tract infection, diabetes mellitus (DM), obesity, dyslipidemia, testosterone level, PSA level, TNF-α and TGF-β level in prostatic tissue is the most affecting factor to prostatic volume.

Method:
We conducted an analytical retrospective cohort study with data collected from the medical record. We enrolled 83 BPH Balinese patients who underwent TURP with benign histopathologic results. The baseline data were not significantly different. Bivariate analysis (Spearman’s test) were used to find the correlation between risk factors and prostatic volume.

Result:

There was a positive correlation between PSA level and prostatic volume (p<0.001) and between testosterone level and prostatic volume (p=0.059, significantly moderate). Multivariate analysis (linear regression) concluded that PSA level and testosterone level affect the prostatic volume. For every 1 ng/ml raise in PSA value, there will be 1.4 ml prostatic volume enlargement (p<0.001) and for every 1 ng/ml raise in testosterone level, there will be 0.024 ml prostatic volume enlargement (p=0.005). We concluded that PSA level and testosterone level are the most affecting factors to the prostatic volume.

Keywords: pembesaran prostat jinak pembesaran volume prostat PSA testosteron

References

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How to Cite

Sari, Y. A., Duarsa, G. W. K., & Mahadewa, T. G. B. (2019). Faktor risiko yang mempengaruhi pembesaran volume prostat pada pasien pembesaran prostat jinak yang dilakukan reseksi prostat transuretra. Medicina, 50(2). https://doi.org/10.15562/medicina.v50i2.702
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Yudit Anastasia Sari
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Medicina Journal

Gede Wirya Kusuma Duarsa
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Tjokorda Gde Bagus Mahadewa
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