Skip to main content Skip to main navigation menu Skip to site footer

Perbedaan kadar c-reactive protein (crp) dan jumlah leukosit serum ibu antara kehamilan aterm normal dengan ketuban pecah dini aterm di RSUP Sanglah Denpasar

  • Natanael Kurniawan Susanto ,
  • IGP Surya ,
  • I Nyoman Hariyasa Sanjaya ,
  • Made Suyasa Jaya ,
  • I Wayan Megadhana ,
  • IBG Fajar Manuaba ,

Abstract

Premature rupture of membranes (PROM) is one of obstetric problem worldwide. It is high in prevalence, perinatal and maternal morbidity and mortality. Infection is one of the risk factors for PROM. The occurrence of infection can be detected using serum CRP level and leukocyte count examination. The study was cross-sectional design. Samples was divided into 2 groups, the term PROM group (36 people) and the normal term pregnancy group (36 people). The research sample is maternal peripheral blood taken by consecutive sampling. The blood was taken from cubital vein as much as 5 ml, then 3 ml for CRP serum level test and 2 ml for leukocyte count test. Then the samples were sent to the Emergency Department Laboratory at Sanglah General Hospital Denpasar. From a total of 72 samples obtained that age, parity and ANC were not significantly different in two groups (p> 0.05). CRP serum level and leukocyte count in term PROM pregnancies were significantly higher than CRP serum level and leukocyte count in normal term pregnancies (p <0.05). This study concludes that there are differences in CRP serum level between normal term pregnancies and term PROM pregnancies. There are differences in the serum leukocyte count between normal term pregnancies and term PROM.

 

Ketuban pecah dini  merupakan salah satu komplikasi kehamilan yang menjadi masalah di bidang obstetri di seluruh dunia termasuk di Indonesia, terkait dengan prevalensi, morbiditas dan mortalitas perinatal maupun maternal. Salah satu faktor risiko KPD adalah infeksi. Untuk mendeteksi adanya infeksi diperlukan pemeriksaan serum CRP dan jumlah leukosit. Rancangan penelitian ini adalah cross-sectional study. Sampel dibedakan menjadi 2 kelompok, yaitu kelompok kehamilan KPD aterm (36 orang) dan kehamilan normal aterm (36 orang). Sampel penelitian berupa pengambilan sampel darah yang diambil dengan cara consecutive sampling. Dilakukan pengambilan darah vena cubiti sebanyak 5 ml, selanjutnya 3 ml untuk pemeriksaan serum CRP dan 2 ml untuk pemeriksaan leukosit. Sampel selanjutnya dikirim ke Laboratorium IGD RSUP Sanglah Denpasar. Pada penelitian ini didapatkan total 72 sampel. Karakteristik umur, paritas dan ANC tidak terdapat perbedaan bermakna pada dua kelompok (p>0,05). CRP dan jumlah leukosit serum pada kehamilan KPD aterm lebih tinggi secara bermakna dibanding CRP dan jumlah leukosit pada kehamilan normal aterm (p<0,05). Penelitian ini menyimpulkan bahwa terdapat perbedaan kadar CRP antara kehamilan aterm normal dengan kehamilan KPD aterm. Terdapat perbedaan jumlah leukosit serum antara kehamilan aterm normal dengan KPD aterm.

References

  1. Getahun, D., Stricland, D., Ananth, C.,Fasset., Kirby., Jacobsen. 2012. Reccurent of Preterm Ruptured of Membranes In Relation to Interval Between Pregnancy. Am J Obstet and Ginecol. United States of America. Vol 220. pp570. El-6
  2. Liu X., Watkins K., Hussey., Luchok J., Amankra S. N. 2010. Effect of Maternal Stress on Low Birth Weight and Preterm Birth Outcomes Across Neighborhoods of South Carolina. J Maternal and Child Health. Vol 14 (2): 215-226.
  3. Maryunani, A. 2013. Asuhan Kegawatdaruratan Maternal & Neonatal. Jakarta : Trans Info Medika.
  4. Soewarto, S. 2012. Ketuban Pecah Dini. Ilmu Kebidanan. Edisi Keempat. Jakarta: PT Bina Pustaka Sarwono Prawirohardjo. Hal 677-682.
  5. Suwiyoga., Budayasa, R., Soetjiningsih. 2006. Peranan Faktor Resiko Ketuban Pecah Dini Terhadap Insidens Sepsis Neonatorum Dini pada Kehamilan Aterm. http://www.kalbe.co.id, 18 Desember 2016.
  6. Cunningham, F. G. 2010. Preterm Birth. Obstetric Williams 23rd. The McGraw-Hill Company, New York. 804-831.
  7. Martinez, R.D., Smith, P., Lamont, R. 2007. Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. BJOG. 114:796-801.
  8. Banaem, L.M., Mohamadi, B., Jaafarabadi, M.A., Moghadam, N.A. 2011. Maternal Serum C-reactive Protein in Early Pregnancy and Occurence of Preterm Premature rupture of Membranes and Preterm Birth. Journal of Obstetrics and Gynecology Research, Vol. 38. 780–786.
  9. Nakishbandy, B.M., Barawi, S. 2014. Level of C-reactive protein as an indicator prognosis of premature uterine contractions. Journal of Prenatal Medicine. 8(1/2):25-30.
  10. Patil, S. & Patil, V. 2014. Maternal and Foetal Outcome in Premature Rupture of Membranes. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 13(12): 56-81.
  11. Blecher, L. I., Mailloux, B. 2011. 'Cesarean section', dalam Pfenninger, JL., Fowler, GC. (eds) Procedures for Primary Care. Edisi 3. USA: Elsevier, pp. 1105-12.
  12. Svenvik, M., Brudin, L., Blomberg, M. 2015. Preterm birth: a prominent risk factor for low apgar scores. BioMed Research Inernational. 2015: 978079.
  13. Deb, N., Sinha, R.R., Sagar, S. 2018. Significance of C-reactive proteins (CRP) in the prediction of patients with premature rupture of membranes. JMSCR. 6 (12): 940-2.
  14. Wiwanitkit, V., 2005. Maternal C-reactive protein for detection of chorioamnionitis: An appraisal. Infect. Dis. Obstet. Gynecol., 13: 179-181.
  15. Perrone, G., Anceschi, M.M., Capri, O., Galoppi, P., Pizzulo, S., Buccheri, M., dkk. 2012. Maternal C-reactive protein at hospital admission is a simple predictor of funisitis in preterm premature rupture of membranes. Gynecol Obstet Invest. 74: 95-9.
  16. Broumand, F., Naji S., Seivani S. 2018. Predictive values of maternal serum levels of procalcitonin, ESR, CRP, and WBC in the diagnosis of chorioamnionitis in mothers with preterm premature rupture of membrane. Iranian Journal of Neonatology. 9 (2). doi:10.22038/ijn.2018.24735.1317
  17. Jarc, K., Carli, T., Lucovnik, M., Srsen, T.P., Cerar, L.K., Derganc, M. 2013. Maternal serum C-reactive protein and white blood cell count in the prediction of chorioamnionitis and fetal inflammatory response after preterm rupture of membranes. Gynaecol Perinatol. 22(4): 165-9.

How to Cite

Susanto, N. K., Surya, I., Sanjaya, I. N. H., Jaya, M. S., Megadhana, I. W., & Manuaba, I. F. (2020). Perbedaan kadar c-reactive protein (crp) dan jumlah leukosit serum ibu antara kehamilan aterm normal dengan ketuban pecah dini aterm di RSUP Sanglah Denpasar. Medicina, 51(3). https://doi.org/10.15562/medicina.v51i3.892

HTML
285

Total
569

Share

Search Panel