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Perbedaan kadar c-reactive protein (crp) dan jumlah leukosit serum ibu antara kehamilan aterm normal dengan ketuban pecah dini aterm di RSUP Sanglah Denpasar

  • Natanael Kurniawan Susanto ,
  • IGP Surya ,
  • I Nyoman Hariyasa Sanjaya ,
  • Made Suyasa Jaya ,
  • I Wayan Megadhana ,
  • IBG Fajar Manuaba ,


Abstract

Premature rupture of membranes (PROM) is one of obstetric problem worldwide. It is high in prevalence, perinatal and maternal morbidity and mortality. Infection is one of the risk factors for PROM. The occurrence of infection can be detected using serum CRP level and leukocyte count examination. The study was cross-sectional design. Samples was divided into 2 groups, the term PROM group (36 people) and the normal term pregnancy group (36 people). The research sample is maternal peripheral blood taken by consecutive sampling. The blood was taken from cubital vein as much as 5 ml, then 3 ml for CRP serum level test and 2 ml for leukocyte count test. Then the samples were sent to the Emergency Department Laboratory at Sanglah General Hospital Denpasar. From a total of 72 samples obtained that age, parity and ANC were not significantly different in two groups (p> 0.05). CRP serum level and leukocyte count in term PROM pregnancies were significantly higher than CRP serum level and leukocyte count in normal term pregnancies (p <0.05). This study concludes that there are differences in CRP serum level between normal term pregnancies and term PROM pregnancies. There are differences in the serum leukocyte count between normal term pregnancies and term PROM.

 

Ketuban pecah dini  merupakan salah satu komplikasi kehamilan yang menjadi masalah di bidang obstetri di seluruh dunia termasuk di Indonesia, terkait dengan prevalensi, morbiditas dan mortalitas perinatal maupun maternal. Salah satu faktor risiko KPD adalah infeksi. Untuk mendeteksi adanya infeksi diperlukan pemeriksaan serum CRP dan jumlah leukosit. Rancangan penelitian ini adalah cross-sectional study. Sampel dibedakan menjadi 2 kelompok, yaitu kelompok kehamilan KPD aterm (36 orang) dan kehamilan normal aterm (36 orang). Sampel penelitian berupa pengambilan sampel darah yang diambil dengan cara consecutive sampling. Dilakukan pengambilan darah vena cubiti sebanyak 5 ml, selanjutnya 3 ml untuk pemeriksaan serum CRP dan 2 ml untuk pemeriksaan leukosit. Sampel selanjutnya dikirim ke Laboratorium IGD RSUP Sanglah Denpasar. Pada penelitian ini didapatkan total 72 sampel. Karakteristik umur, paritas dan ANC tidak terdapat perbedaan bermakna pada dua kelompok (p>0,05). CRP dan jumlah leukosit serum pada kehamilan KPD aterm lebih tinggi secara bermakna dibanding CRP dan jumlah leukosit pada kehamilan normal aterm (p<0,05). Penelitian ini menyimpulkan bahwa terdapat perbedaan kadar CRP antara kehamilan aterm normal dengan kehamilan KPD aterm. Terdapat perbedaan jumlah leukosit serum antara kehamilan aterm normal dengan KPD aterm.

Keywords: KPD aterm CRP leukosit serum

References

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How to Cite

Susanto, N. K., Surya, I., Sanjaya, I. N. H., Jaya, M. S., Megadhana, I. W., & Manuaba, I. F. (2020). Perbedaan kadar c-reactive protein (crp) dan jumlah leukosit serum ibu antara kehamilan aterm normal dengan ketuban pecah dini aterm di RSUP Sanglah Denpasar. Medicina, 51(3). https://doi.org/10.15562/medicina.v51i3.892
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Natanael Kurniawan Susanto
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IGP Surya
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I Nyoman Hariyasa Sanjaya
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Made Suyasa Jaya
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I Wayan Megadhana
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IBG Fajar Manuaba
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